Search results for " Rat Langendorff heart"

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Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA(1-64)) in the rat heart

2010

Cytoskeleton scaffold in cardiac myocytes provides structural support and compartmentalization of intracellular components. It is implicated in cardiac pathologies including hypertrophy and failure, playing a key role in the determinism of contractile and diastolic dysfunctions. Chromogranin A (CgA) and its derived peptides have revealed themselves as novel cardiovascular modulators. In humans, normal CgA levels considerably increase in several pathologies, including heart failure. Recent data have shown on the unstimulated rat heart that human recombinant Vasostatin-1 (hrVS-1) and rat chromogranin A 1-64 (rCgA(1-64)) induce negative inotropic and lusitropic effects counteracting the beta-a…

medicine.medical_specialtyMESH: RatsPhysiologyPhalloidin[SDV]Life Sciences [q-bio]Clinical BiochemistryMESH: Myocytes Cardiacmacromolecular substancesBiologyBiochemistryWortmanninCellular and Molecular Neurosciencechemistry.chemical_compoundEndocrinologyInternal medicineMyosinmedicineMESH: CytoskeletonMyocyteMESH: AnimalsCytoskeletonActinMESH: In Vitro TechniquesMESH: HumansSettore BIO/16 - Anatomia UmanaChromogranin AMESH: Rats WistarMESH: MaleCell biologyMESH: Cell LineMESH: Heart[SDV] Life Sciences [q-bio]EndocrinologychemistryInotropismVasostatin Rat CgA1-64 Rat Langendorff heart Inotropy Lusitropy Cardiomyocytes Cytoskeletonbiology.proteinMESH: Chromogranin A

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